Pharmacogenetic Testing South Africa | DNAMeds
Your DNA decides
how medicine works
We all carry tiny variations in our DNA that are unique to us. Because of them, two people taking the same medication can have very different experiences — from no relief at all, to severe pain, cramping, or hospitalization from adverse drug reactions.
The Science
One DNA test. A lifetime of safer prescriptions.
DNAMeds identifies genetic variations that may influence how you respond to certain medicines. These insights help your healthcare professional make more informed prescribing decisions alongside your medical history, other medicines and clinical assessment.
Are all PGx tests the same?
No, all Pharmacogenomic tests are not the same. Our test has been carefully curated to offer you the maximum clinical value by testing those genes that are clinically actionable COMPREHENSIVELY across disease areas.
Our analysis and interpretation platform ensures that you have the most clinically robust recommendations vetted by expertly trained pharmacists that help you and your Doctors understand the technical report.
Each test includes a FREE consultation with an expertly trained Pharmacogenomics Consultant Pharmacist.
Your Metabolizer Status
Four ways your body handles a drug
The drug is broken down very slowly. Standard doses build up and may cause side effects or toxicity.
Lower dose or alternative drug
Your body processes the medication as expected. Standard dosing typically works as intended.
Standard dose
The drug is cleared faster than average. You may need a higher dose to feel the therapeutic effect.
Increased dose may be needed
The medication is broken down so quickly that it may not work — or, for prodrugs, may become dangerous.
Alternative drug recommended
Free Pre-Check
Check your medications for possible interactions
List every medication and supplement you currently take. We'll flag potential drug-drug interactions and show which ones a PGx test could clarify — before you commit to one.
Educational use only — not a substitute for advice from your prescriber or pharmacist. Do not change any medication without speaking to your clinician.
Common Medications Affected
Where genetic variation matters most
Cardiovascular
Anticoagulants, Beta-Blockers, Antiplatelets, Statins
Gastroenterology
Proton-Pump Inhibitors
Infectious Disease
Antivirals, Antifungals
Neurology & Anesthesia
Anticonvulsants, Anesthetics
Pulmonology
Ivacaftor
Acute Hemolytic Anemia
Primaquine, Dapsone, Rasburicase
Psychiatry
SSRIs, Tricyclic Antidepressants
Pain & Antiemetics
NSAIDs, Opioids, 5-HT3 Antagonists
Oncology
Fluoropyrimidines, Thiopurines, Estrogen Modulators
Immunology / Transplants
Immunosuppressants
The 29-Gene Panel
Genes we analyze and why they matter
Each gene below influences how your body activates, breaks down, or reacts to specific medications.
ABCG2
Transporter affecting rosuvastatin and allopurinol exposure and response.
BCHE
Butyrylcholinesterase — prolonged apnea risk with succinylcholine and mivacurium.
CACNA1S
Malignant hyperthermia susceptibility with volatile anesthetics.
CFTR
Ivacaftor and modulator response in cystic fibrosis.
CYP2B6
Efavirenz, bupropion, methadone metabolism.
CYP2C cluster
Combined haplotype context for the CYP2C gene region.
CYP2C19
Activates clopidogrel; metabolizes PPIs, SSRIs, voriconazole.
CYP2C9
Warfarin, NSAIDs, phenytoin metabolism.
CYP2D6
Metabolizes ~25% of all prescription drugs (antidepressants, opioids, antipsychotics, tamoxifen).
CYP3A4
Largest drug-metabolizing enzyme; statins, immunosuppressants.
CYP3A5
Tacrolimus dosing in transplant patients.
CYP4F2
Vitamin K recycling — warfarin dosing.
DPYD
Fluoropyrimidine (5-FU, capecitabine) toxicity risk.
FII
Prothrombin (Factor II) — thrombosis risk relevant to anticoagulation.
FV
Factor V Leiden — thrombosis risk relevant to anticoagulation and hormonal therapy.
G6PD
Hemolytic anemia risk with primaquine, dapsone, rasburicase.
HLA-A
Carbamazepine hypersensitivity (HLA-A*31:01).
HLA-B
Severe hypersensitivity to abacavir, carbamazepine, allopurinol.
IFNL3/4
Response to pegylated interferon for hepatitis C.
MT-RNR1
Aminoglycoside-induced hearing loss.
NAT2
Isoniazid, sulfonamide metabolism.
NUDT15
Thiopurine toxicity, especially in Asian populations.
RYR1
Malignant hyperthermia with volatile anesthetics.
SLCO1B1
Statin-induced myopathy risk.
TPMT
Thiopurine (azathioprine, mercaptopurine) toxicity risk.
UGT1A1
Irinotecan, atazanavir — Gilbert syndrome.
VKORC1
Warfarin sensitivity.
Full Coverage
Every drug covered by our DNAMeds List
A 29-gene panel covering more than 260 medications across every major therapeutic area — from cardiology to oncology, psychiatry to pain management.
Addiction
3- lofexidine
- buprenorphine
- methadone
Alzheimer's Disease
1- aducanumab
Anesthesiology
14- bupivacaine
- chloroprocaine
- desflurane
- enflurane
- halothane
- isoflurane
- mepivacaine
- metabutethamine
- methoxyflurane
- oxymetazoline & tetracaine
- prilocaine
- ropivacaine
- sevoflurane
- succinylcholine
Cardiology
30- acenocoumarol
- atorvastatin
- bisoprolol & perindopril
- carvedilol
- clopidogrel
- fenofibrate
- flecainide
- fluindione
- fluvastatin
- hydralazine
- losartan
- lovastatin
- mavacamten
- metoprolol
- nebivolol
- nicorandil
- nitroglycerin
- perindopril
- pitavastatin
- prasugrel
- pravastatin
- procainamide
- propafenone
- propranolol
- ranolazine
- rosuvastatin
- simvastatin
- ticagrelor
- timolol
- warfarin
Cystic Fibrosis
1- ivacaftor
Dental
2- articaine & epinephrine
- cevimeline
Dermatology
4- abrocitinib
- deuruxolitinib
- lidocaine & prilocaine
- lidocaine & tetracaine
Dietary Supplement
1- vitamin C
Endocrinology
10- chlorpropamide
- gliclazide
- glimepiride
- glipizide
- glyburide
- nateglinide
- pioglitazone
- saxagliptin
- tolazamide
- tolbutamide
Fever
1- paracetamol
Gastroenterology
11- dexlansoprazole
- dronabinol
- esomeprazole
- lansoprazole
- meclizine
- metoclopramide
- omeprazole
- ondansetron
- pantoprazole
- rabeprazole
- tropisetron
Gaucher's Disease
1- eliglustat
Gynaecology
4- drospirenone & ethinyl estradiol
- elagolix
- estrogen-containing contraceptives
- flibanserin
Hematology
4- avatrombopag
- eltrombopag
- lusutrombopag
- phenprocoumon
Immunology
3- cyclosporine
- sirolimus
- tacrolimus
Infectious Diseases
52- 4-aminosalicylic acid
- amikacin
- atazanavir
- chloroquine
- ciprofloxacin
- dapsone
- dasabuvir
- dibekacin
- dolutegravir
- efavirenz
- flucloxacillin
- flucytosine
- gentamicin
- hydroxychloroquine
- isoniazid
- kanamycin
- ketoconazole
- mafenide
- maraviroc
- methylene blue
- moxifloxacin
- nalidixic acid
- neomycin
- netilmicin
- nevirapine
- nitrofurantoin
- norfloxacin
- ofloxacin
- paromomycin
- peginterferon alfa-2A
- peginterferon alfa-2A + ribavirin
- peginterferon alfa-2A + ribavirin + boceprevir
- peginterferon alfa-2A + ribavirin + simeprevir
- peginterferon alfa-2A + ribavirin + telaprevir
- peginterferon alfa-2B
- peginterferon alfa-2B + ribavirin
- peginterferon alfa-2B + ribavirin + boceprevir
- peginterferon alfa-2B + ribavirin + simeprevir
- peginterferon alfa-2B + ribavirin + telaprevir
- plazomicin
- primaquine
- quinine
- raltegravir
- ribostamycin
- sofosbuvir
- streptomycin
- sulfadiazine
- sulfamethoxazole
- sulfamethoxazole & trimethoprim
- tafenoquine
- tobramycin
- voriconazole
Neurology
19- alprazolam
- amifampridine
- amifampridine phosphate
- belzutifan
- brivaracetam
- clobazam
- clonazepam
- deutetrabenazine
- dextromethorphan & quinidine
- diazepam
- donepezil
- fosphenytoin
- galantamine
- lamotrigine
- mivacurium
- phenytoin
- siponimod
- tetrabenazine
- valbenazine
Oncology
21- 5-fluorouracil
- allopurinol
- belinostat
- capecitabine
- cisplatin
- dabrafenib
- doxorubicin
- erdafitinib
- erlotinib
- flutamide
- gefitinib
- irinotecan
- mercaptopurine
- nilotinib
- pazopanib
- rasburicase
- sacituzumab govitecan-hziy
- tamoxifen
- tegafur
- thioguanine
- toluidine blue
Pain
20- aspirin
- carbasalate calcium
- carisoprodol
- celecoxib
- codeine
- diclofenac
- dihydrocodeine
- fentanyl
- flurbiprofen
- hydrocodone
- ibuprofen
- lornoxicam
- meloxicam
- oliceridine
- oxycodone
- piroxicam
- sufentanil
- tenoxicam
- tolperisone
- tramadol
Psychiatry
47- amitriptyline
- amoxapine
- amphetamine
- aripiprazole
- aripiprazole lauroxil
- atomoxetine
- brexpiprazole
- bupropion
- buspirone
- citalopram
- clomipramine
- clozapine
- desipramine
- dextromethorphan
- dextromethorphan & bupropion
- doxepin
- duloxetine
- escitalopram
- eszopiclone
- fluoxetine
- flupenthixol
- fluvoxamine
- guanfacine
- haloperidol
- iloperidone
- imipramine
- mirtazapine
- moclobemide
- nortriptyline
- olanzapine
- paroxetine
- perphenazine
- pimozide
- pitolisant
- protriptyline
- quetiapine
- risperidone
- sertindole
- sertraline
- thioridazine
- trazodone
- trimipramine
- venlafaxine
- desvenlafaxine
- viloxazine
- vortioxetine
- zuclopenthixol
Rheumatology
4- azathioprine
- lesinurad
- pegloticase
- sulfasalazine
Toxicology
1- sodium nitrite
Urology
6- dapoxetine
- darifenacin
- fesoterodine
- mirabegron
- tamsulosin
- tolterodine
Ready to read your code?
One Sample. A lifetime of more precise, safer prescriptions for you and your family.